| 6. Ronde | 11.02.2021 | LD Alajuelense | - | Municipal Grecia | 3:0 | ||||
| 8. Ronde | 15.02.2021 | AD San Carlos | - | Municipal Grecia | 1:4 | ||||
| 9. Ronde | 21.02.2021 | Guadalupe | - | Municipal Grecia | 1:1 |  |
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| 10. Ronde | 27.02.2021 | Municipal Grecia | - | CS Cartaginés | 1:2 | ||||
| 11. Ronde | 04.03.2021 | Municipal Grecia | - | Santos de Guápiles | 1:2 | ||||
| 12. Ronde | 07.03.2021 | Deportivo Saprissa | - | Municipal Grecia | 1:2 | ||||
| 13. Ronde | 13.03.2021 | Sporting FC | - | Municipal Grecia | 0:0 | ||||
| 14. Ronde | 20.03.2021 | Municipal Grecia | - | CS Herediano | 1:4 | |
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| 16. Ronde | 03.04.2021 | Municipal Grecia | - | Limón FC | 2:2 | ||||
| 17. Ronde | 09.04.2021 | Municipal Grecia | - | LD Alajuelense | 1:4 | |
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| 15. Ronde | 15.04.2021 | Municipal Pérez Zeledón | - | Municipal Grecia | 1:1 | ||||
| 18. Ronde | 18.04.2021 | Jicaral | - | Municipal Grecia | 1:0 | ||||
| 19. Ronde | 22.04.2021 | Municipal Grecia | - | AD San Carlos | 2:1 | ||||
| 20. Ronde | 25.04.2021 | Municipal Grecia | - | Guadalupe | 0:0 | ||||
| 21. Ronde | 01.05.2021 | CS Cartaginés | - | Municipal Grecia | 2:0 |
Panama