| 2. Ronde | 07.08.2021 | Cobán Imperial | - | Sololá FC | 0:0 | ||||
| 4. Ronde | 14.08.2021 | Cobán Imperial | - | Achuapa | 2:0 |  |
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| 3. Ronde | 18.08.2021 | Nueva Concepción | - | Cobán Imperial | 2:1 | ||||
| 6. Ronde | 25.08.2021 | Deportivo Malacateco | - | Cobán Imperial | 1:0 | ||||
| 7. Ronde | 29.08.2021 | Cobán Imperial | - | Antigua GFC | 0:2 | ||||
| 9. Ronde | 11.09.2021 | Cobán Imperial | - | Santa Lucía | 0:1 | ||||
| 10. Ronde | 18.09.2021 | CSD Municipal | - | Cobán Imperial | 2:1 | ||||
| 11. Ronde | 25.09.2021 | Cobán Imperial | - | Iztapa | 2:1 | |
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| 8. Ronde | 13.10.2021 | Deportivo Guastatoya | - | Cobán Imperial | 0:1 | ||||
| 14. Ronde | 17.10.2021 | Cobán Imperial | - | Nueva Concepción | 2:0 | ||||
| 15. Ronde | 23.10.2021 | Achuapa | - | Cobán Imperial | 1:0 | ||||
| 16. Ronde | 27.10.2021 | Cobán Imperial | - | Comunicaciones | 1:2 | |
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| 17. Ronde | 31.10.2021 | Cobán Imperial | - | Deportivo Malacateco | 1:1 | ||||
| 18. Ronde | 07.11.2021 | Antigua GFC | - | Cobán Imperial | 2:1 | ||||
| 19. Ronde | 13.11.2021 | Cobán Imperial | - | Deportivo Guastatoya | 0:1 | |
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| 21. Ronde | 28.11.2021 | Cobán Imperial | - | CSD Municipal | 0:1 | ||||
| 22. Ronde | 05.12.2021 | Iztapa | - | Cobán Imperial | 5:3 |
Guatemala