| 1. Ronde | 24.07.2021 | Aucas | - | Mushuc Runa | 1:1 | ||||
| 3. Ronde | 07.08.2021 | Mushuc Runa | - | Independiente del Valle | 0:2 | ||||
| 4. Ronde | 15.08.2021 | Manta | - | Mushuc Runa | 0:0 | ||||
| 5. Ronde | 21.08.2021 | Macará | - | Mushuc Runa | 1:1 | ||||
| 6. Ronde | 29.08.2021 | Mushuc Runa | - | LDU Quito | 1:3 | ||||
| 7. Ronde | 19.09.2021 | Olmedo | - | Mushuc Runa | 2:5 | ||||
| 8. Ronde | 25.09.2021 | Mushuc Runa | - | Orense SC | 0:0 |  |
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| 9. Ronde | 03.10.2021 | Barcelona | - | Mushuc Runa | 4:0 | ||||
| 10. Ronde | 17.10.2021 | Mushuc Runa | - | Técnico Universitario | 0:1 | ||||
| 11. Ronde | 23.10.2021 | Universidad Catolica | - | Mushuc Runa | 0:1 | ||||
| 12. Ronde | 31.10.2021 | Mushuc Runa | - | Deportivo Cuenca | 1:0 | ||||
| 14. Ronde | 21.11.2021 | Mushuc Runa | - | Guayaquil City | 1:0 |
Ecuador