| 1. Ronde | 22.02.2021 | Alianza | - | Sporting San Miguelito | 0:0 | ||||
| 2. Ronde | 28.02.2021 | Sporting San Miguelito | - | Plaza Amador | 0:0 | ||||
| 3. Ronde | 08.03.2021 | Tauro FC | - | Sporting San Miguelito | 0:1 | ||||
| 5. Ronde | 18.03.2021 | Sporting San Miguelito | - | Árabe Unido | 3:2 |  |
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| 6. Ronde | 21.03.2021 | UD Universitario | - | Sporting San Miguelito | 2:1 | ||||
| 7. Ronde | 24.03.2021 | Sporting San Miguelito | - | Independiente de La Chorrera | 1:3 | ||||
| 9. Ronde | 05.04.2021 | Herrera FC | - | Sporting San Miguelito | 2:0 | ||||
| 10. Ronde | 10.04.2021 | San Francisco FC | - | Sporting San Miguelito | 2:0 | |
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| 13. Ronde | 25.04.2021 | Plaza Amador | - | Sporting San Miguelito | 2:1 | |
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| 14. Ronde | 28.04.2021 | Sporting San Miguelito | - | Tauro FC | 2:2 | |
Panama