| 1. Ronde | 18.07.2021 | Club Olimpia | - | River Plate | 1:3 | ||||
| 2. Ronde | 25.07.2021 | Guaireña FC | - | River Plate | 1:2 | ||||
| 3. Ronde | 31.07.2021 | River Plate | - | Cerro Porteño | 0:0 | ||||
| 4. Ronde | 09.08.2021 | Sol de América | - | River Plate | 1:0 |  |
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| 5. Ronde | 14.08.2021 | River Plate | - | Club Nacional | 1:0 | ||||
| 6. Ronde | 22.08.2021 | 12 de Octubre de Itauguá | - | River Plate | 2:2 | ||||
| 7. Ronde | 30.08.2021 | River Plate | - | Guaraní | 1:5 |
Paraguay