| 1. Ronde | 26.07.2021 | CF Monterrey | - | Puebla FC | 1:1 |  |
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| 3. Ronde | 08.08.2021 | CF América | - | Puebla FC | 2:0 | ||||
| 4. Ronde | 14.08.2021 | Puebla FC | - | UANL Tigres | 1:1 | ||||
| 5. Ronde | 18.08.2021 | Club Tijuana | - | Puebla FC | 1:1 | ||||
| 6. Ronde | 22.08.2021 | Pumas UNAM | - | Puebla FC | 2:0 | ||||
| 7. Ronde | 28.08.2021 | Puebla FC | - | Gallos Blancos | 1:0 | ||||
| 8. Ronde | 11.09.2021 | Puebla FC | - | Atlético San Luis | 2:2 | ||||
| 9. Ronde | 20.09.2021 | Santos Laguna | - | Puebla FC | 1:1 | ||||
| 10. Ronde | 25.09.2021 | Puebla FC | - | Cruz Azul | 1:1 | ||||
| 11. Ronde | 29.09.2021 | Atlas Guadalajara | - | Puebla FC | 0:1 | |
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| 12. Ronde | 02.10.2021 | Puebla FC | - | CF Pachuca | 1:2 | |
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| 13. Ronde | 16.10.2021 | Club Necaxa | - | Puebla FC | 0:1 | ||||
| 14. Ronde | 20.10.2021 | Puebla FC | - | Mazatlán FC | 2:0 | |
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| 15. Ronde | 24.10.2021 | Puebla FC | - | Club León | 0:1 | |
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| 16. Ronde | 30.10.2021 | FC Juárez | - | Puebla FC | 0:2 | |
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| 17. Ronde | 06.11.2021 | Puebla FC | - | Deportivo Toluca | 1:0 | |
Uruguay
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