| 5. Ronde | 13.02.2022 | Cruz Azul | - | Club Necaxa | 1:2 | ||||
| 6. Ronde | 21.02.2022 | Deportivo Toluca | - | Cruz Azul | 1:4 | ||||
| 11. Ronde | 20.03.2022 | CF Pachuca | - | Cruz Azul | 1:0 | ||||
| 12. Ronde | 03.04.2022 | Cruz Azul | - | Atlas Guadalajara | 1:0 | ||||
| 13. Ronde | 09.04.2022 | Mazatlán FC | - | Cruz Azul | 1:1 |  |
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| 14. Ronde | 17.04.2022 | Cruz Azul | - | Deportivo Guadalajara | 0:1 | ||||
| 15. Ronde | 22.04.2022 | Gallos Blancos | - | Cruz Azul | 0:1 | |
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| 16. Ronde | 25.04.2022 | Cruz Azul | - | Atlético San Luis | 0:1 | ||||
| 17. Ronde | 01.05.2022 | CF América | - | Cruz Azul | 0:0 |
Uruguay
Spanje