| 1. Ronde | 03.07.2022 | UANL Tigres | - | Cruz Azul | 2:3 | ||||
| 2. Ronde | 10.07.2022 | Cruz Azul | - | CF Pachuca | 1:2 | ||||
| 3. Ronde | 17.07.2022 | Atlas Guadalajara | - | Cruz Azul | 3:2 |  |
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| 4. Ronde | 24.07.2022 | Cruz Azul | - | Puebla FC | 2:2 | ||||
| 5. Ronde | 27.07.2022 | Atlético San Luis | - | Cruz Azul | 0:0 | |
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| 7. Ronde | 07.08.2022 | Santos Laguna | - | Cruz Azul | 4:0 | ||||
| 8. Ronde | 15.08.2022 | Cruz Azul | - | Deportivo Toluca | 2:3 | ||||
| 9. Ronde | 18.08.2022 | Cruz Azul | - | Club Tijuana | 1:2 | ||||
| 11. Ronde | 28.08.2022 | Cruz Azul | - | Gallos Blancos | 2:1 | |
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| 12. Ronde | 03.09.2022 | FC Juárez | - | Cruz Azul | 2:2 | ||||
| 13. Ronde | 07.09.2022 | CF Monterrey | - | Cruz Azul | 3:2 | |
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| 14. Ronde | 11.09.2022 | Cruz Azul | - | Mazatlán FC | 2:0 | ||||
| 16. Ronde | 16.09.2022 | Cruz Azul | - | Club León | 2:1 | ||||
| 15. Ronde | 19.09.2022 | Pumas UNAM | - | Cruz Azul | 1:2 | |
Uruguay
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