| 2. Ronde | 21.08.2021 | Royal Excel Mouscron | - | Lommel SK | 0:1 | ||||
| 3. Ronde | 29.08.2021 | Royal Excel Mouscron | - | Waasland-Beveren | 0:4 | ||||
| 4. Ronde | 10.09.2021 | SK Deinze | - | Royal Excel Mouscron | 3:1 | ||||
| 5. Ronde | 18.09.2021 | Royal Excel Mouscron | - | Excelsior Virton | 1:1 | ||||
| 6. Ronde | 26.09.2021 | Royal Excel Mouscron | - | KVC Westerlo | 1:2 |  |
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| 7. Ronde | 02.10.2021 | Lierse Kempenzonen | - | Royal Excel Mouscron | 2:2 | ||||
| 14. Ronde | 05.12.2021 | KVC Westerlo | - | Royal Excel Mouscron | 4:3 | ||||
| 15. Ronde | 11.12.2021 | Royal Excel Mouscron | - | Lommel SK | 2:1 | |
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| 16. Ronde | 18.12.2021 | SK Deinze | - | Royal Excel Mouscron | 2:2 |  |
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| 17. Ronde | 23.01.2022 | Royal Excel Mouscron | - | Lierse Kempenzonen | 0:0 | ||||
| 18. Ronde | 30.01.2022 | RWD Molenbeek | - | Royal Excel Mouscron | 2:0 | ||||
| 19. Ronde | 05.02.2022 | Royal Excel Mouscron | - | Waasland-Beveren | 3:0 | ||||
| 21. Ronde | 20.02.2022 | Royal Excel Mouscron | - | Excelsior Virton | 2:1 | ||||
| 24. Ronde | 13.03.2022 | Lierse Kempenzonen | - | Royal Excel Mouscron | 0:1 | ||||
| 26. Ronde | 03.04.2022 | Excelsior Virton | - | Royal Excel Mouscron | 2:0 |
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