| 1. Ronde | 12.09.2021 | Volos NFC | - | Lamia | 2:1 | ||||
| 2. Ronde | 19.09.2021 | Lamia | - | Olympiakos | 1:2 | ||||
| 3. Ronde | 22.09.2021 | AEK Athene | - | Lamia | 1:0 | ||||
| 6. Ronde | 18.10.2021 | Lamia | - | Aris Saloniki | 0:1 |  |
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| 8. Ronde | 31.10.2021 | Lamia | - | Atromitos | 2:2 | ||||
| 9. Ronde | 07.11.2021 | Asteras Tripolis | - | Lamia | 0:1 | ||||
| 11. Ronde | 27.11.2021 | Apollon Smyrnis | - | Lamia | 0:0 | ||||
| 12. Ronde | 06.12.2021 | Lamia | - | PAS Giannina | 0:1 | ||||
| 13. Ronde | 12.12.2021 | PAOK Saloniki | - | Lamia | 2:1 | ||||
| 14. Ronde | 15.12.2021 | Lamia | - | Volos NFC | 2:2 | ||||
| 15. Ronde | 19.12.2021 | Olympiakos | - | Lamia | 1:0 | ||||
| 16. Ronde | 05.01.2022 | Lamia | - | AEK Athene | 0:2 | ||||
| 21. Ronde | 10.02.2022 | Atromitos | - | Lamia | 3:1 |  |
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| 23. Ronde | 13.02.2022 | Panathinaikos | - | Lamia | 2:0 | ||||
| 22. Ronde | 23.02.2022 | Lamia | - | Asteras Tripolis | 0:2 | ||||
| 25. Ronde | 28.02.2022 | PAS Giannina | - | Lamia | 1:0 | ||||
| 26. Ronde | 06.03.2022 | Lamia | - | PAOK Saloniki | 0:2 |
Griekenland