| 8. Ronde | 12.09.2021 | Sportivo Luqueño | - | River Plate | 0:2 | ||||
| 11. Ronde | 03.10.2021 | River Plate | - | Guaireña FC | 1:1 | ||||
| 12. Ronde | 19.10.2021 | Cerro Porteño | - | River Plate | 2:0 |  |
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| 13. Ronde | 23.10.2021 | River Plate | - | Sol de América | 0:2 | ||||
| 14. Ronde | 30.10.2021 | Club Nacional | - | River Plate | 1:1 | ||||
| 15. Ronde | 05.11.2021 | River Plate | - | 12 de Octubre de Itauguá | 0:2 | ||||
| 17. Ronde | 26.11.2021 | River Plate | - | Sportivo Luqueño | 0:0 |
Paraguay