| 1. Ronde | 18.01.2021 | Deportes Tolima | - | Once Caldas | 1:1 |  |
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| 6. Ronde | 15.02.2021 | Deportivo Pasto | - | Deportes Tolima | 0:1 | |
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| 9. Ronde | 26.02.2021 | Alianza Petrolera | - | Deportes Tolima | 0:5 | ||||
| 2. Ronde | 05.03.2021 | Santa Fe | - | Deportes Tolima | 3:2 | ||||
| 13. Ronde | 21.03.2021 | Deportivo Cali | - | Deportes Tolima | 0:0 | ||||
| 16. Ronde | 31.03.2021 | Deportes Tolima | - | Atlético Nacional | 2:1 | ||||
| 19. Ronde | 18.04.2021 | América de Cali | - | Deportes Tolima | 2:0 |
Colombia