| 1. Ronde | 11.07.2022 | Deportes Tolima | - | Independiente Medellín | 1:1 | ||||
| 2. Ronde | 15.07.2022 | Deportes Tolima | - | Deportivo Cali | 2:0 | ||||
| 3. Ronde | 19.07.2022 | Unión Magdalena | - | Deportes Tolima | 2:1 |  |
|||
| 5. Ronde | 02.08.2022 | Atlético Bucaramanga | - | Deportes Tolima | 2:1 | |
|||
| 7. Ronde | 14.08.2022 | Santa Fe | - | Deportes Tolima | 2:1 | |
|||
| 9. Ronde | 29.08.2022 | Atlético Junior | - | Deportes Tolima | 2:1 | ||||
| 10. Ronde | 04.09.2022 | Deportes Tolima | - | Cortuluá | 0:0 | ||||
| 11. Ronde | 10.09.2022 | Patriotas FC | - | Deportes Tolima | 1:1 | |
|||
| 12. Ronde | 17.09.2022 | Deportes Tolima | - | Once Caldas | 1:0 | ||||
| 13. Ronde | 22.09.2022 | América de Cali | - | Deportes Tolima | 0:0 | ||||
| 15. Ronde | 02.10.2022 | Águilas Doradas | - | Deportes Tolima | 1:2 | ||||
| 16. Ronde | 09.10.2022 | Deportivo Pasto | - | Deportes Tolima | 2:1 | |
|||
| 18. Ronde | 16.10.2022 | Cortuluá | - | Deportes Tolima | 0:1 | ||||
| 19. Ronde | 23.10.2022 | Deportes Tolima | - | Millonarios | 1:0 | |
|||
| 20. Ronde | 29.10.2022 | Envigado FC | - | Deportes Tolima | 1:1 |
Colombia