| 2. Ronde | 29.08.2010 | Defensor Sporting | - | Liverpool | 3:0 | ||||
| 4. Ronde | 19.09.2010 | Defensor Sporting | - | Montevideo Wanderers | 1:2 | ||||
| 6. Ronde | 02.10.2010 | Defensor Sporting | - | Bella Vista | 1:2 | ||||
| 5. Ronde | 12.10.2010 | Defensor Sporting | - | El Tanque Sisley | 3:1 | ||||
| 8. Ronde | 16.10.2010 | Danubio | - | Defensor Sporting | 1:1 | ||||
| 9. Ronde | 24.10.2010 | Defensor Sporting | - | Rampla Juniors | 4:1 | ||||
| 10. Ronde | 31.10.2010 | Defensor Sporting | - | Fénix | 5:1 | ||||
| 11. Ronde | 06.11.2010 | Racing | - | Defensor Sporting | 0:3 | ||||
| 12. Ronde | 13.11.2010 | Defensor Sporting | - | Central Español | 1:1 |  |
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| 13. Ronde | 20.11.2010 | Peñarol | - | Defensor Sporting | 0:1 |  |
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| 14. Ronde | 27.11.2010 | Defensor Sporting | - | Nacional | 1:2 |  |
Uruguay
Spanje