| 1. Ronde | 30.07.2000 | NK Osijek | - | NK Zagreb | 4:3 |  |
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| 3. Ronde | 13.08.2000 | NK Osijek | - | NK Čakovec | 4:3 | ||||
| 4. Ronde | 19.08.2000 | HNK Cibalia | - | NK Osijek | 1:1 |  |
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| 5. Ronde | 29.08.2000 | NK Osijek | - | HNK Rijeka | 1:2 | ||||
| 6. Ronde | 09.09.2000 | Dinamo Zagreb | - | NK Osijek | 0:1 |  |
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| 7. Ronde | 19.09.2000 | NK Osijek | - | Hrvatski Dragovoljac | 6:2 | ||||
| 8. Ronde | 23.09.2000 | NK Varteks | - | NK Osijek | 2:3 | |
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| 10. Ronde | 04.10.2000 | NK Osijek | - | Hajduk Split | 2:1 | ||||
| 9. Ronde | 08.10.2000 | NK Osijek | - | HNK Šibenik | 2:0 | ||||
| 13. Ronde | 29.10.2000 | NK Osijek | - | Slaven Belupo | 3:0 | ||||
| 14. Ronde | 02.11.2000 | NK Čakovec | - | NK Osijek | 0:1 | ||||
| 15. Ronde | 12.11.2000 | NK Osijek | - | HNK Cibalia | 3:0 | ||||
| 16. Ronde | 17.11.2000 | HNK Rijeka | - | NK Osijek | 2:3 | ||||
| 17. Ronde | 29.11.2000 | NK Osijek | - | Dinamo Zagreb | 1:1 | |
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| 19. Ronde | 24.02.2001 | NK Osijek | - | NK Varteks | 4:1 | ||||
| 20. Ronde | 04.03.2001 | HNK Šibenik | - | NK Osijek | 1:0 | ||||
| 21. Ronde | 10.03.2001 | Hajduk Split | - | NK Osijek | 1:1 | ||||
| 22. Ronde | 18.03.2001 | NK Osijek | - | NK Marsonia | 1:2 | |
Kroatië