| 4. Ronde | 07.02.2021 | Tigres FC | - | Deportes Quindío | 1:1 | ||||
| 5. Ronde | 11.02.2021 | Atlético Huila | - | Tigres FC | 1:0 |  |
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| 6. Ronde | 15.02.2021 | Tigres FC | - | Orsomarso SC | 2:0 | ||||
| 7. Ronde | 20.02.2021 | Cortuluá | - | Tigres FC | 0:0 | ||||
| 8. Ronde | 28.02.2021 | Tigres FC | - | Boca Juniors de Cali | 1:1 | ||||
| 9. Ronde | 03.03.2021 | Atlético FC | - | Tigres FC | 0:1 | ||||
| 10. Ronde | 06.03.2021 | Tigres FC | - | Real Cartagena | 0:0 | ||||
| 11. Ronde | 13.03.2021 | Barranquilla FC | - | Tigres FC | 1:0 | ||||
| 12. Ronde | 21.03.2021 | Tigres FC | - | Real Santander | 1:1 | |
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| 13. Ronde | 27.03.2021 | Valledupar FC | - | Tigres FC | 0:0 | ||||
| 14. Ronde | 05.04.2021 | Tigres FC | - | Bogotá FC | 0:2 |  |
Colombia