| 3. Ronde | 01.08.2021 | Libertad | - | Sol de América | 1:1 |  |
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| 4. Ronde | 07.08.2021 | Club Nacional | - | Libertad | 1:0 | ||||
| 6. Ronde | 24.08.2021 | Guaraní | - | Libertad | 2:2 | |
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| 7. Ronde | 29.08.2021 | Libertad | - | Sportivo Luqueño | 5:0 | ||||
| 8. Ronde | 13.09.2021 | Libertad | - | Club Olimpia | 0:3 | ||||
| 9. Ronde | 18.09.2021 | River Plate | - | Libertad | 0:1 | ||||
| 11. Ronde | 04.10.2021 | Libertad | - | Cerro Porteño | 0:2 | ||||
| 12. Ronde | 17.10.2021 | Sol de América | - | Libertad | 0:4 | ||||
| 13. Ronde | 25.10.2021 | Libertad | - | Club Nacional | 1:2 | ||||
| 14. Ronde | 30.10.2021 | 12 de Octubre de Itauguá | - | Libertad | 0:1 | ||||
| 15. Ronde | 07.11.2021 | Libertad | - | Guaraní | 2:0 | ||||
| 16. Ronde | 20.11.2021 | Sportivo Luqueño | - | Libertad | 2:2 | ||||
| 17. Ronde | 26.11.2021 | Club Olimpia | - | Libertad | 2:3 | ||||
| 18. Ronde | 03.12.2021 | Libertad | - | River Plate | 5:0 |
Colombia