| 1. Ronde | 23.01.2022 | Tigres FC | - | Real Cartagena | 1:2 | ||||
| 2. Ronde | 01.02.2022 | Real Cartagena | - | Fortaleza FC | 1:1 | ||||
| 4. Ronde | 15.02.2022 | Real Cartagena | - | Atlético Huila | 1:1 | ||||
| 7. Ronde | 06.03.2022 | Real Cartagena | - | Atlético FC | 0:0 |  |
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| 8. Ronde | 10.03.2022 | Leones FC | - | Real Cartagena | 1:0 | ||||
| 9. Ronde | 19.03.2022 | Real Cartagena | - | Bogotá FC | 1:1 | ||||
| 10. Ronde | 28.03.2022 | Orsomarso SC | - | Real Cartagena | 1:2 | |
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| 12. Ronde | 13.04.2022 | Deportes Quindío | - | Real Cartagena | 5:0 | ||||
| 13. Ronde | 20.04.2022 | Real Cartagena | - | Boyacá Chicó | 3:1 | ||||
| 14. Ronde | 25.04.2022 | Boca Juniors de Cali | - | Real Cartagena | 1:2 | ||||
| 15. Ronde | 04.05.2022 | Real Cartagena | - | Valledupar FC | 1:2 |
Colombia