| 1. Ronde | 21.08.2021 | FC Lisse | - | ACV Assen | 2:3 | ||||
| 2. Ronde | 28.08.2021 | ACV Assen | - | Hoek | 1:1 | ||||
| 3. Ronde | 04.09.2021 | VVOG | - | ACV Assen | 2:4 |  |
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| 4. Ronde | 11.09.2021 | ACV Assen | - | Sparta Nijkerk | 2:2 | ||||
| 5. Ronde | 18.09.2021 | DOVO | - | ACV Assen | 1:2 | ||||
| 6. Ronde | 25.09.2021 | ACV Assen | - | Harkemase Boys | 0:1 | ||||
| 7. Ronde | 02.10.2021 | ACV Assen | - | Ter Leede | 0:1 | ||||
| 8. Ronde | 09.10.2021 | VVSB | - | ACV Assen | 0:3 | ||||
| 9. Ronde | 16.10.2021 | ACV Assen | - | Sportlust '46 | 1:2 | ||||
| 10. Ronde | 30.10.2021 | SteDoCo | - | ACV Assen | 2:1 | ||||
| 12. Ronde | 13.11.2021 | DVS'33 | - | ACV Assen | 1:0 |  |
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| 13. Ronde | 20.11.2021 | ACV Assen | - | Staphorst | 2:1 | ||||
| 14. Ronde | 27.11.2021 | Excelsior '31 | - | ACV Assen | 3:0 | |
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| 15. Ronde | 19.02.2022 | ACV Assen | - | Ajax (amateurs) | 0:0 | ||||
| 16. Ronde | 26.02.2022 | ACV Assen | - | ODIN '59 | 0:1 | ||||
| 17. Ronde | 05.03.2022 | Barendrecht | - | ACV Assen | 1:1 | ||||
| 26. Ronde | 18.04.2022 | Sparta Nijkerk | - | ACV Assen | 2:2 | ||||
| 27. Ronde | 23.04.2022 | ACV Assen | - | Barendrecht | 4:1 | ||||
| 28. Ronde | 30.04.2022 | Ajax (amateurs) | - | ACV Assen | 0:2 | ||||
| 29. Ronde | 07.05.2022 | ACV Assen | - | DVS'33 | 1:3 |
Nederland