| 1. Ronde | 25.07.2021 | MFK Zemplín Michalovce | - | FC DAC 1904 | 4:1 | ||||
| 2. Ronde | 01.08.2021 | FC DAC 1904 | - | Tatran Liptovský Mikuláš | 3:1 | ||||
| 3. Ronde | 08.08.2021 | ŠKF Sereď | - | FC DAC 1904 | 1:0 |  |
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| 4. Ronde | 14.08.2021 | FK Senica | - | FC DAC 1904 | 1:1 | |
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| 5. Ronde | 22.08.2021 | FC DAC 1904 | - | AS Trenčín | 1:1 |  |
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| 6. Ronde | 27.08.2021 | FK Pohronie | - | FC DAC 1904 | 0:3 | ||||
| 7. Ronde | 12.09.2021 | FC DAC 1904 | - | Slovan Bratislava | 1:1 | ||||
| 8. Ronde | 18.09.2021 | MFK Ružomberok | - | FC DAC 1904 | 1:2 | ||||
| 9. Ronde | 26.09.2021 | FC DAC 1904 | - | Spartak Trnava | 0:3 | ||||
| 12. Ronde | 24.10.2021 | FC DAC 1904 | - | MFK Zemplín Michalovce | 1:0 | ||||
| 13. Ronde | 30.10.2021 | Tatran Liptovský Mikuláš | - | FC DAC 1904 | 1:0 |
Oekraïne