| 1. Ronde | 23.08.2015 | Sampdoria | - | Carpi FC | 5:2 |  |
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| 3. Ronde | 14.09.2015 | Sampdoria | - | Bologna FC | 2:0 | ||||
| 4. Ronde | 20.09.2015 | Torino FC | - | Sampdoria | 2:0 | ||||
| 5. Ronde | 23.09.2015 | Sampdoria | - | AS Roma | 2:1 | ||||
| 7. Ronde | 04.10.2015 | Sampdoria | - | Inter | 1:1 | ||||
| 8. Ronde | 18.10.2015 | Frosinone Calcio | - | Sampdoria | 2:0 |  |
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| 9. Ronde | 25.10.2015 | Sampdoria | - | Hellas Verona | 4:1 | ||||
| 11. Ronde | 02.11.2015 | Chievo Verona | - | Sampdoria | 1:1 | ||||
| 12. Ronde | 08.11.2015 | Sampdoria | - | ACF Fiorentina | 0:2 | ||||
| 14. Ronde | 28.11.2015 | AC Milan | - | Sampdoria | 4:1 | ||||
| 16. Ronde | 14.12.2015 | Lazio | - | Sampdoria | 1:1 | ||||
| 17. Ronde | 20.12.2015 | Sampdoria | - | US Palermo | 2:0 |  |
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| 19. Ronde | 10.01.2016 | Sampdoria | - | Juventus | 1:2 | ||||
| 21. Ronde | 24.01.2016 | Sampdoria | - | SSC Napoli | 2:4 | ||||
| 22. Ronde | 31.01.2016 | Bologna FC | - | Sampdoria | 3:2 | |
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| 23. Ronde | 03.02.2016 | Sampdoria | - | Torino FC | 2:2 | ||||
| 24. Ronde | 07.02.2016 | AS Roma | - | Sampdoria | 2:1 | ||||
| 25. Ronde | 14.02.2016 | Sampdoria | - | Atalanta | 0:0 | |
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| 26. Ronde | 20.02.2016 | Inter | - | Sampdoria | 3:1 | ||||
| 31. Ronde | 03.04.2016 | ACF Fiorentina | - | Sampdoria | 1:1 | ||||
| 32. Ronde | 10.04.2016 | Sampdoria | - | Udinese Calcio | 2:0 |
Slowakije