| 1. Ronde | 06.02.2022 | Albion | - | Rentistas | 3:5 |  |
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| 2. Ronde | 13.02.2022 | Liverpool | - | Albion | 4:0 |  |
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| 3. Ronde | 20.02.2022 | Albion | - | Peñarol | 1:1 | |
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| 5. Ronde | 13.03.2022 | Albion | - | Montevideo Wanderers | 1:1 | ||||
| 6. Ronde | 20.03.2022 | Plaza Colonia | - | Albion | 1:1 | ||||
| 8. Ronde | 10.04.2022 | River Plate | - | Albion | 4:1 | ||||
| 11. Ronde | 07.05.2022 | Albion | - | Defensor Sporting | 0:3 | ||||
| 12. Ronde | 15.05.2022 | Albion | - | Cerrito | 2:2 | ||||
| 13. Ronde | 21.05.2022 | Nacional | - | Albion | 2:0 |
Uruguay