| 2. Ronde | 03.08.2021 | LDU Quito | - | Olmedo | 4:0 | ||||
| 3. Ronde | 10.08.2021 | Macará | - | Olmedo | 3:2 | ||||
| 4. Ronde | 17.08.2021 | Olmedo | - | 9 de Octubre | 1:2 | ||||
| 6. Ronde | 28.08.2021 | Emelec | - | Olmedo | 4:0 | ||||
| 7. Ronde | 19.09.2021 | Olmedo | - | Mushuc Runa | 2:5 | ||||
| 8. Ronde | 26.09.2021 | Deportivo Cuenca | - | Olmedo | 5:0 | ||||
| 9. Ronde | 03.10.2021 | Olmedo | - | Aucas | 1:4 | ||||
| 10. Ronde | 16.10.2021 | Guayaquil City | - | Olmedo | 4:2 | ||||
| 11. Ronde | 24.10.2021 | Olmedo | - | Delfín SC | 1:3 |  |
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| 12. Ronde | 31.10.2021 | Independiente del Valle | - | Olmedo | 5:0 | ||||
| 13. Ronde | 07.11.2021 | Olmedo | - | Barcelona | 0:2 | ||||
| 14. Ronde | 21.11.2021 | Manta | - | Olmedo | 3:0 |
Ecuador