| 1. Ronde | 06.02.2021 | 12 de Octubre de Itauguá | - | River Plate | 2:2 | ||||
| 2. Ronde | 09.02.2021 | River Plate | - | Guaraní | 1:4 |  |
|||
| 3. Ronde | 15.02.2021 | Sol de América | - | River Plate | 1:1 |  |
|||
| 4. Ronde | 19.02.2021 | River Plate | - | Sportivo Luqueño | 1:0 | |
|||
| 5. Ronde | 02.03.2021 | Libertad | - | River Plate | 2:1 | |
|||
| 6. Ronde | 05.03.2021 | River Plate | - | Guaireña FC | 0:1 | ||||
| 10. Ronde | 02.04.2021 | River Plate | - | 12 de Octubre de Itauguá | 0:2 | ||||
| 11. Ronde | 13.04.2021 | Guaraní | - | River Plate | 2:0 | ||||
| 13. Ronde | 27.04.2021 | Sportivo Luqueño | - | River Plate | 2:2 |
Paraguay