| 6. Ronde | 18.08.2021 | CS Herediano | - | AD San Carlos | 2:0 | ||||
| 7. Ronde | 26.08.2021 | Santos de Guápiles | - | CS Herediano | 2:1 | ||||
| 13. Ronde | 26.09.2021 | CS Herediano | - | Jicaral | 1:0 |  |
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| 14. Ronde | 04.10.2021 | CS Herediano | - | Deportivo Saprissa | 2:1 | |
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| 15. Ronde | 13.10.2021 | Municipal Pérez Zeledón | - | CS Herediano | 0:1 | |
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| 16. Ronde | 17.10.2021 | CS Herediano | - | LD Alajuelense | 0:0 |  |
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| 19. Ronde | 31.10.2021 | CS Cartaginés | - | CS Herediano | 0:1 | |
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| 22. Ronde | 28.11.2021 | Sporting FC | - | CS Herediano | 0:2 |  |
Mexico