| 7. Ronde | 06.09.2021 | Tigres FC | - | Real Santander | 2:0 | ||||
| 8. Ronde | 11.09.2021 | Real Santander | - | Barranquilla FC | 1:1 |  |
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| 9. Ronde | 18.09.2021 | Bogotá FC | - | Real Santander | 1:1 | ||||
| 10. Ronde | 24.09.2021 | Real Santander | - | Atlético FC | 0:2 | ||||
| 11. Ronde | 02.10.2021 | Orsomarso SC | - | Real Santander | 3:1 | ||||
| 12. Ronde | 09.10.2021 | Real Santander | - | Valledupar FC | 1:1 | ||||
| 13. Ronde | 20.10.2021 | Boyacá Chicó | - | Real Santander | 3:1 | ||||
| 14. Ronde | 24.10.2021 | Real Santander | - | Fortaleza FC | 1:1 |
Colombia