| 1. Ronde | 25.08.2010 | River Plate | - | Defensor Sporting | 1:1 | ||||
| 2. Ronde | 29.08.2010 | Defensor Sporting | - | Liverpool | 3:0 | ||||
| 4. Ronde | 19.09.2010 | Defensor Sporting | - | Montevideo Wanderers | 1:2 | ||||
| 3. Ronde | 06.10.2010 | Defensor Sporting | - | CA Cerro | 2:0 | ||||
| 7. Ronde | 09.10.2010 | Miramar Misiones | - | Defensor Sporting | 0:1 |  |
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| 5. Ronde | 12.10.2010 | Defensor Sporting | - | El Tanque Sisley | 3:1 | |
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| 8. Ronde | 16.10.2010 | Danubio | - | Defensor Sporting | 1:1 | ||||
| 9. Ronde | 24.10.2010 | Defensor Sporting | - | Rampla Juniors | 4:1 | ||||
| 10. Ronde | 31.10.2010 | Defensor Sporting | - | Fénix | 5:1 | ||||
| 11. Ronde | 06.11.2010 | Racing | - | Defensor Sporting | 0:3 | |
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| 12. Ronde | 13.11.2010 | Defensor Sporting | - | Central Español | 1:1 | ||||
| 13. Ronde | 20.11.2010 | Peñarol | - | Defensor Sporting | 0:1 | ||||
| 14. Ronde | 27.11.2010 | Defensor Sporting | - | Nacional | 1:2 | ||||
| 15. Ronde | 05.12.2010 | Tacuarembó | - | Defensor Sporting | 1:3 |
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