| 2. Ronde | 22.05.2021 | Boston River | - | Rentistas | 1:2 | ||||
| 4. Ronde | 06.06.2021 | Boston River | - | Montevideo City Torque | 1:2 | ||||
| 5. Ronde | 14.06.2021 | Villa Española | - | Boston River | 2:2 | ||||
| 7. Ronde | 23.06.2021 | Cerrito | - | Boston River | 1:0 | ||||
| 14. Ronde | 16.08.2021 | Boston River | - | Fénix | 0:2 | ||||
| 15. Ronde | 21.08.2021 | Deportivo Maldonado | - | Boston River | 0:2 |
Uruguay