| 4. Ronde | 25.06.2021 | Uruguay Montevideo | - | Albion | 2:2 |  |
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| 5. Ronde | 02.07.2021 | Uruguay Montevideo | - | Rampla Juniors | 2:0 | ||||
| 17. Ronde | 19.10.2021 | Uruguay Montevideo | - | Danubio | 2:3 | ||||
| 18. Ronde | 27.10.2021 | Rocha | - | Uruguay Montevideo | 1:2 | |
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| 19. Ronde | 03.11.2021 | Uruguay Montevideo | - | CA Cerro | 1:2 | ||||
| 20. Ronde | 10.11.2021 | Defensor Sporting | - | Uruguay Montevideo | 2:0 | ||||
| 21. Ronde | 18.11.2021 | Uruguay Montevideo | - | Central Español | 0:3 | ||||
| 22. Ronde | 23.11.2021 | Atenas | - | Uruguay Montevideo | 0:0 |
Uruguay