| 1. Ronde | 23.02.2025 | Columbus Crew | - | Chicago Fire | 4:2 |  |
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| 2. Ronde | 02.03.2025 | New England Revolution | - | Columbus Crew | 0:1 | ||||
| 3. Ronde | 08.03.2025 | Columbus Crew | - | Houston Dynamo | 0:0 | ||||
| 4. Ronde | 16.03.2025 | San Diego FC | - | Columbus Crew | 1:1 |  |
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| 5. Ronde | 23.03.2025 | Columbus Crew | - | New York City FC | 0:0 | ||||
| 6. Ronde | 30.03.2025 | D.C. United | - | Columbus Crew | 1:2 | |
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| 7. Ronde | 06.04.2025 | Columbus Crew | - | CF Montréal | 2:1 | ||||
| 8. Ronde | 14.04.2025 | St. Louis City SC | - | Columbus Crew | 1:2 | |
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| 9. Ronde | 19.04.2025 | Columbus Crew | - | Inter Miami CF | 0:1 | ||||
| 10. Ronde | 27.04.2025 | Columbus Crew | - | San Jose Earthquakes | 2:1 | ||||
| 11. Ronde | 04.05.2025 | Columbus Crew | - | Charlotte FC | 4:2 | |
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| 12. Ronde | 11.05.2025 | Philadelphia Union | - | Columbus Crew | 2:2 | ||||
| 14. Ronde | 18.05.2025 | Columbus Crew | - | FC Cincinnati | 1:1 | |
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| 15. Ronde | 25.05.2025 | Charlotte FC | - | Columbus Crew | 3:2 | ||||
| 16. Ronde | 29.05.2025 | Columbus Crew | - | Nashville SC | 2:2 | |
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| 17. Ronde | 01.06.2025 | Inter Miami CF | - | Columbus Crew | 5:1 |
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