| 1. Ronde | 15.01.2021 | CS Cartaginés | - | Santos de Guápiles | 1:0 | ||||
| 2. Ronde | 17.01.2021 | CS Cartaginés | - | Guadalupe | 2:1 | ||||
| 3. Ronde | 22.01.2021 | Municipal Pérez Zeledón | - | CS Cartaginés | 2:1 | ||||
| 4. Ronde | 25.01.2021 | CS Cartaginés | - | Limón FC | 1:1 | ||||
| 5. Ronde | 31.01.2021 | Deportivo Saprissa | - | CS Cartaginés | 4:1 | ||||
| 6. Ronde | 04.02.2021 | AD San Carlos | - | CS Cartaginés | 1:1 |  |
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| 7. Ronde | 07.02.2021 | CS Cartaginés | - | CS Herediano | 1:2 | ||||
| 8. Ronde | 14.02.2021 | Sporting FC | - | CS Cartaginés | 3:1 | ||||
| 9. Ronde | 21.02.2021 | CS Cartaginés | - | LD Alajuelense | 1:1 | ||||
| 10. Ronde | 27.02.2021 | Municipal Grecia | - | CS Cartaginés | 1:2 | |
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| 11. Ronde | 03.03.2021 | CS Cartaginés | - | Jicaral | 1:1 | ||||
| 12. Ronde | 09.03.2021 | Santos de Guápiles | - | CS Cartaginés | 1:0 | ||||
| 17. Ronde | 10.04.2021 | CS Cartaginés | - | AD San Carlos | 1:1 | |
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| 18. Ronde | 18.04.2021 | CS Herediano | - | CS Cartaginés | 1:2 | ||||
| 19. Ronde | 21.04.2021 | CS Cartaginés | - | Sporting FC | 0:1 | ||||
| 22. Ronde | 13.05.2021 | Jicaral | - | CS Cartaginés | 1:0 |
Costa Rica
Guatemala