| 1. Ronde | 28.07.2021 | Municipal Grecia | - | CS Cartaginés | 4:0 |  |
|||
| 2. Ronde | 31.07.2021 | CS Cartaginés | - | AD Guanacasteca | 1:1 | ||||
| 3. Ronde | 08.08.2021 | LD Alajuelense | - | CS Cartaginés | 2:3 | |
|||
| 4. Ronde | 11.08.2021 | CS Cartaginés | - | AD San Carlos | 5:1 | ||||
| 9. Ronde | 08.09.2021 | CS Cartaginés | - | Municipal Pérez Zeledón | 2:1 | ||||
| 10. Ronde | 12.09.2021 | CS Cartaginés | - | Santos de Guápiles | 1:2 | ||||
| 11. Ronde | 15.09.2021 | Jicaral | - | CS Cartaginés | 0:3 | |
|||
| 12. Ronde | 19.09.2021 | CS Cartaginés | - | Municipal Grecia | 1:1 |  |
|||
| 13. Ronde | 25.09.2021 | AD Guanacasteca | - | CS Cartaginés | 2:1 | ||||
| 14. Ronde | 03.10.2021 | CS Cartaginés | - | LD Alajuelense | 1:0 | ||||
| 15. Ronde | 13.10.2021 | AD San Carlos | - | CS Cartaginés | 0:1 | ||||
| 16. Ronde | 19.10.2021 | CS Cartaginés | - | Sporting FC | 1:0 | ||||
| 17. Ronde | 25.10.2021 | Deportivo Saprissa | - | CS Cartaginés | 1:1 | ||||
| 18. Ronde | 27.10.2021 | Guadalupe | - | CS Cartaginés | 1:1 | ||||
| 19. Ronde | 31.10.2021 | CS Cartaginés | - | CS Herediano | 0:1 | ||||
| 21. Ronde | 25.11.2021 | Santos de Guápiles | - | CS Cartaginés | 1:2 | ||||
| 22. Ronde | 28.11.2021 | CS Cartaginés | - | Jicaral | 4:0 |
Costa Rica
Guatemala