| 1. Ronde | 13.01.2022 | Guadalupe | - | CS Cartaginés | 3:2 |  |
|||
| 3. Ronde | 23.01.2022 | Deportivo Saprissa | - | CS Cartaginés | 2:4 | ||||
| 4. Ronde | 04.02.2022 | CS Cartaginés | - | Sporting FC | 2:1 | ||||
| 5. Ronde | 10.02.2022 | LD Alajuelense | - | CS Cartaginés | 3:2 | ||||
| 6. Ronde | 13.02.2022 | Municipal Grecia | - | CS Cartaginés | 2:0 | ||||
| 8. Ronde | 28.02.2022 | Santos de Guápiles | - | CS Cartaginés | 1:3 | ||||
| 9. Ronde | 02.03.2022 | CS Cartaginés | - | AD San Carlos | 1:1 | ||||
| 10. Ronde | 06.03.2022 | AD Guanacasteca | - | CS Cartaginés | 1:1 |  |
|||
| 14. Ronde | 17.04.2022 | CS Cartaginés | - | Deportivo Saprissa | 3:1 | ||||
| 16. Ronde | 24.04.2022 | CS Cartaginés | - | LD Alajuelense | 1:2 | ||||
| 17. Ronde | 27.04.2022 | CS Cartaginés | - | Municipal Grecia | 4:0 | ||||
| 18. Ronde | 01.05.2022 | CS Herediano | - | CS Cartaginés | 4:1 | ||||
| 19. Ronde | 04.05.2022 | CS Cartaginés | - | Santos de Guápiles | 4:1 | ||||
| 20. Ronde | 09.05.2022 | AD San Carlos | - | CS Cartaginés | 3:2 | ||||
| 21. Ronde | 12.05.2022 | CS Cartaginés | - | AD Guanacasteca | 3:0 |
Costa Rica
Guatemala