| 1. Ronde | 07.08.2021 | Northampton Town | - | Port Vale FC | 1:0 |  |
|||
| 4. Ronde | 21.08.2021 | Northampton Town | - | Rochdale AFC | 1:3 | ||||
| 5. Ronde | 28.08.2021 | Crawley Town | - | Northampton Town | 0:0 | |
|||
| 6. Ronde | 04.09.2021 | Northampton Town | - | Scunthorpe United | 2:0 | ||||
| 7. Ronde | 11.09.2021 | Forest Green Rovers | - | Northampton Town | 1:0 | ||||
| 3. Ronde | 14.09.2021 | Newport County | - | Northampton Town | 0:1 | ||||
| 8. Ronde | 18.09.2021 | Northampton Town | - | Swindon Town | 1:1 | ||||
| 9. Ronde | 25.09.2021 | Salford City | - | Northampton Town | 2:2 | ||||
| 11. Ronde | 09.10.2021 | Hartlepool United | - | Northampton Town | 2:1 | ||||
| 13. Ronde | 19.10.2021 | Northampton Town | - | Stevenage FC | 3:0 | ||||
| 16. Ronde | 13.11.2021 | Bristol Rovers | - | Northampton Town | 2:1 | ||||
| 18. Ronde | 23.11.2021 | Northampton Town | - | Oldham Athletic | 2:1 | ||||
| 21. Ronde | 11.12.2021 | Harrogate Town | - | Northampton Town | 1:2 | ||||
| 25. Ronde | 01.01.2022 | Swindon Town | - | Northampton Town | 5:2 | ||||
| 26. Ronde | 08.01.2022 | Northampton Town | - | Crawley Town | 0:1 | ||||
| 27. Ronde | 15.01.2022 | Northampton Town | - | Forest Green Rovers | 1:1 | ||||
| 28. Ronde | 22.01.2022 | Sutton United | - | Northampton Town | 0:0 |
Ierland