| 29. Ronde | 25.08.2021 | Chacaritas FC | - | Atlético Porteño | 2:1 | ||||
| 30. Ronde | 01.09.2021 | Gualaceo SC | - | Chacaritas FC | 0:1 |  |
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| 31. Ronde | 08.09.2021 | Chacaritas FC | - | El Nacional | 1:1 |  |
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| 32. Ronde | 15.09.2021 | Independiente Juniors | - | Chacaritas FC | 2:0 | ||||
| 33. Ronde | 22.09.2021 | Chacaritas FC | - | Guayaquil SC | 4:1 | ||||
| 35. Ronde | 06.10.2021 | Liga de Portoviejo | - | Chacaritas FC | 1:0 | ||||
| 36. Ronde | 13.10.2021 | Chacaritas FC | - | América de Quito | 2:2 |
Ecuador