| 12. Ronde | 15.09.2021 | Danubio | - | Central Español | 1:1 | ||||
| 13. Ronde | 21.09.2021 | Atenas | - | Danubio | 0:2 | ||||
| 14. Ronde | 29.09.2021 | Danubio | - | Racing | 2:0 |  |
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| 15. Ronde | 05.10.2021 | Villa Teresa | - | Danubio | 0:2 |  |
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| 16. Ronde | 13.10.2021 | Danubio | - | Juventud de Las Piedras | 0:1 | ||||
| 17. Ronde | 19.10.2021 | Uruguay Montevideo | - | Danubio | 2:3 | |
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| 18. Ronde | 28.10.2021 | Danubio | - | Rampla Juniors | 2:0 | ||||
| 19. Ronde | 01.11.2021 | Albion | - | Danubio | 2:1 | ||||
| 20. Ronde | 10.11.2021 | Rocha | - | Danubio | 1:2 | |
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| 21. Ronde | 18.11.2021 | Danubio | - | CA Cerro | 0:0 | |
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| 22. Ronde | 24.11.2021 | Defensor Sporting | - | Danubio | 0:1 |
Uruguay