| 17. Ronde | 20.10.2021 | Racing | - | Defensor Sporting | 0:1 | ||||
| 18. Ronde | 29.10.2021 | Defensor Sporting | - | Villa Teresa | 1:2 | ||||
| 19. Ronde | 02.11.2021 | Juventud de Las Piedras | - | Defensor Sporting | 3:3 |  |
|||
| 20. Ronde | 10.11.2021 | Defensor Sporting | - | Uruguay Montevideo | 2:0 | ||||
| 21. Ronde | 18.11.2021 | Rampla Juniors | - | Defensor Sporting | 0:5 | ||||
| 22. Ronde | 24.11.2021 | Defensor Sporting | - | Danubio | 0:1 |
Uruguay