| 2. Ronde | 19.09.2021 | Fortuna Düsseldorf [A-jun] | - | FC Schalke 04 [A-jun] | 0:1 | ||||
| 3. Ronde | 26.09.2021 | FC Schalke 04 [A-jun] | - | Alemannia Aachen [A-jun] | 5:0 | ||||
| 4. Ronde | 02.10.2021 | Bayer Leverkusen [A-jun] | - | FC Schalke 04 [A-jun] | 2:2 | ||||
| 8. Ronde | 28.11.2021 | Bor. Mönchengladbach [A-jun] | - | FC Schalke 04 [A-jun] | 1:1 | ||||
| 9. Ronde | 05.12.2021 | FC Schalke 04 [A-jun] | - | VfL Bochum [A-jun] | 0:1 | ||||
| 10. Ronde | 06.02.2022 | Preußen Münster [A-jun] | - | FC Schalke 04 [A-jun] | 1:3 |  |
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| 11. Ronde | 13.02.2022 | FC Schalke 04 [A-jun] | - | Rot-Weiss Essen [A-jun] | 1:2 |  |
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| 12. Ronde | 20.02.2022 | Rot-Weiß Oberhausen [A-jun] | - | FC Schalke 04 [A-jun] | 0:2 | ||||
| 13. Ronde | 05.03.2022 | FC Schalke 04 [A-jun] | - | SC Paderborn 07 [A-jun] | 1:0 | ||||
| 14. Ronde | 02.04.2022 | Fortuna Köln [A-jun] | - | FC Schalke 04 [A-jun] | 0:3 | ||||
| 15. Ronde | 09.04.2022 | FC Schalke 04 [A-jun] | - | MSV Duisburg [A-jun] | 1:0 | ||||
| 16. Ronde | 23.04.2022 | Arminia Bielefeld [A-jun] | - | FC Schalke 04 [A-jun] | 0:3 |
Verenigde Staten
Frankrijk