| 3. Ronde | 01.02.2021 | Defensor Sporting | - | River Plate | 0:2 | ||||
| 10. Ronde | 28.02.2021 | Defensor Sporting | - | Danubio | 1:1 |  |
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| 11. Ronde | 08.03.2021 | Nacional | - | Defensor Sporting | 2:1 | |
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| 12. Ronde | 12.03.2021 | Defensor Sporting | - | Boston River | 1:2 | ||||
| 13. Ronde | 18.03.2021 | Deportivo Maldonado | - | Defensor Sporting | 2:1 | ||||
| 14. Ronde | 25.03.2021 | Defensor Sporting | - | Rentistas | 0:0 | ||||
| 15. Ronde | 29.03.2021 | Cerro Largo | - | Defensor Sporting | 0:0 |
Uruguay
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