| 1. Ronde | 17.01.2021 | Fénix | - | River Plate | 0:3 Toeg. |  |
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| 2. Ronde | 20.01.2021 | River Plate | - | CA Cerro | 1:2 | ||||
| 3. Ronde | 01.02.2021 | Defensor Sporting | - | River Plate | 0:2 | |
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| 5. Ronde | 08.02.2021 | Nacional | - | River Plate | 3:0 | ||||
| 6. Ronde | 11.02.2021 | River Plate | - | Boston River | 3:1 | |
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| 7. Ronde | 14.02.2021 | Deportivo Maldonado | - | River Plate | 1:2 | ||||
| 8. Ronde | 17.02.2021 | River Plate | - | Rentistas | 1:1 | ||||
| 9. Ronde | 20.02.2021 | River Plate | - | Cerro Largo | 2:0 | |
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| 10. Ronde | 27.02.2021 | River Plate | - | Montevideo Wanderers | 1:1 | |
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| 13. Ronde | 20.03.2021 | River Plate | - | Montevideo City Torque | 1:1 | ||||
| 15. Ronde | 29.03.2021 | River Plate | - | Progreso | 3:2 |
Uruguay