| 1. Ronde | 16.01.2021 | Danubio | - | Cerro Largo | 0:3 | ||||
| 2. Ronde | 20.01.2021 | Cerro Largo | - | Nacional | 0:0 | ||||
| 3. Ronde | 29.01.2021 | Boston River | - | Cerro Largo | 2:1 | ||||
| 4. Ronde | 02.02.2021 | Cerro Largo | - | Deportivo Maldonado | 1:2 |  |
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| 5. Ronde | 06.02.2021 | Rentistas | - | Cerro Largo | 2:1 | ||||
| 6. Ronde | 10.02.2021 | Liverpool | - | Cerro Largo | 3:2 | |
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| 7. Ronde | 13.02.2021 | Cerro Largo | - | Montevideo Wanderers | 1:3 | ||||
| 10. Ronde | 01.03.2021 | Montevideo City Torque | - | Cerro Largo | 0:0 | ||||
| 11. Ronde | 07.03.2021 | Cerro Largo | - | Plaza Colonia | 3:1 | ||||
| 12. Ronde | 14.03.2021 | Cerro Largo | - | Progreso | 1:0 | ||||
| 13. Ronde | 21.03.2021 | Fénix | - | Cerro Largo | 1:0 | ||||
| 14. Ronde | 24.03.2021 | CA Cerro | - | Cerro Largo | 0:1 | |
Uruguay