| 3. Ronde | 12.08.2022 | Boston River | - | River Plate | 1:2 |  |
|||
| 6. Ronde | 21.08.2022 | Defensor Sporting | - | Boston River | 0:1 | ||||
| 5. Ronde | 27.08.2022 | Boston River | - | Fénix | 1:1 | ||||
| 4. Ronde | 04.09.2022 | Cerro Largo | - | Boston River | 1:1 | ||||
| 7. Ronde | 10.09.2022 | Boston River | - | Albion | 1:0 | |
|||
| 8. Ronde | 15.09.2022 | Nacional | - | Boston River | 1:0 | ||||
| 9. Ronde | 19.09.2022 | Boston River | - | Danubio | 0:1 | ||||
| 10. Ronde | 24.09.2022 | Deportivo Maldonado | - | Boston River | 2:1 | ||||
| 11. Ronde | 02.10.2022 | Boston River | - | Rentistas | 3:0 | ||||
| 12. Ronde | 09.10.2022 | Liverpool | - | Boston River | 3:2 | ||||
| 13. Ronde | 13.10.2022 | Boston River | - | Peñarol | 2:1 | ||||
| 14. Ronde | 17.10.2022 | Montevideo City Torque | - | Boston River | 0:2 | |
Uruguay