| 1. Ronde | 14.08.2021 | Mosta FC | - | Birkirkara FC | 0:3 |  |
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| 2. Ronde | 21.08.2021 | Birkirkara FC | - | Hamrun Spartans | 2:1 | |
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| 3. Ronde | 12.09.2021 | Balzan FC | - | Birkirkara FC | 1:2 | |
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| 4. Ronde | 19.09.2021 | Birkirkara FC | - | Floriana FC | 1:1 | |
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| 5. Ronde | 26.09.2021 | Gżira United | - | Birkirkara FC | 1:1 | |
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| 6. Ronde | 16.10.2021 | Birkirkara FC | - | Gudja United | 2:0 | ||||
| 7. Ronde | 24.10.2021 | Sirens FC | - | Birkirkara FC | 3:2 | ||||
| 8. Ronde | 30.10.2021 | Birkirkara FC | - | Hibernians FC | 1:1 | ||||
| 9. Ronde | 21.11.2021 | St. Luċija FC | - | Birkirkara FC | 2:0 | ||||
| 10. Ronde | 27.11.2021 | Birkirkara FC | - | Sliema Wanderers | 2:0 | ||||
| 11. Ronde | 04.12.2021 | Valletta FC | - | Birkirkara FC | 0:0 | ||||
| 13. Ronde | 26.01.2022 | Hamrun Spartans | - | Birkirkara FC | 0:0 | ||||
| 16. Ronde | 30.01.2022 | Birkirkara FC | - | Gżira United | 1:0 | ||||
| 17. Ronde | 06.02.2022 | Gudja United | - | Birkirkara FC | 0:1 | ||||
| 18. Ronde | 13.02.2022 | Birkirkara FC | - | Sirens FC | 1:1 | ||||
| 20. Ronde | 27.02.2022 | Birkirkara FC | - | St. Luċija FC | 2:3 | ||||
| 21. Ronde | 06.03.2022 | Sliema Wanderers | - | Birkirkara FC | 0:0 | ||||
| 22. Ronde | 12.03.2022 | Birkirkara FC | - | Valletta FC | 1:1 |
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