| 1. Ronde | 12.12.2020 | Al Mokawloon | - | Zamalek | 0:2 |  |
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| 2. Ronde | 17.12.2020 | Pyramids FC | - | Zamalek | 1:1 | ||||
| 8. Ronde | 19.01.2021 | Zamalek | - | El Gouna | 1:0 | ||||
| 9. Ronde | 23.01.2021 | Aswan SC | - | Zamalek | 0:0 | ||||
| 10. Ronde | 28.01.2021 | Zamalek | - | Misr lel-Maqasah SC | 4:1 | ||||
| 11. Ronde | 02.02.2021 | Ghazl Al Mehalla | - | Zamalek | 2:1 |  |
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| 13. Ronde | 17.02.2021 | Zamalek | - | Ismaily | 2:1 | |
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| 14. Ronde | 01.03.2021 | Wadi Degla SC | - | Zamalek | 0:0 | ||||
| 15. Ronde | 11.03.2021 | Zamalek | - | Ceramica Cleopatra | 2:0 | ||||
| 4. Ronde | 18.04.2021 | Zamalek | - | Al Ahly SC | 1:2 | ||||
| 16. Ronde | 22.04.2021 | El Entag El Harby | - | Zamalek | 0:2 | ||||
| 17. Ronde | 26.04.2021 | Zamalek | - | National Bank SC | 4:1 | ||||
| 18. Ronde | 29.04.2021 | Zamalek | - | Al Mokawloon | 2:2 | ||||
| 19. Ronde | 02.05.2021 | Zamalek | - | Pyramids FC | 1:1 | |
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| 20. Ronde | 06.05.2021 | Zamalek | - | Smouha Sporting Club | 2:1 | ||||
| 21. Ronde | 10.05.2021 | Al Ahly SC | - | Zamalek | 1:1 | |
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| 22. Ronde | 14.05.2021 | Zamalek | - | ENPPI | 3:1 | ||||
| 23. Ronde | 20.05.2021 | Zamalek | - | Tala'ea El Gaish SC | 2:1 | ||||
| 24. Ronde | 24.05.2021 | Zamalek | - | Al Masry Club | 3:2 |
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