| 15. Ronde | 12.12.2021 | UD Montijo | - | Don Benito | 3:1 | ||||
| 16. Ronde | 19.12.2021 | Don Benito | - | UD Tamaraceite | 2:0 |  |
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| 18. Ronde | 23.01.2022 | CD Mensajero | - | Don Benito | 1:2 |  |
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| 19. Ronde | 30.01.2022 | Don Benito | - | Antequera CF | 1:1 | ||||
| 20. Ronde | 06.02.2022 | CD San Roque de Lepe | - | Don Benito | 1:0 | ||||
| 21. Ronde | 13.02.2022 | Don Benito | - | Córdoba CF | 1:2 | |
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| 23. Ronde | 27.02.2022 | Don Benito | - | CF Villanovense | 1:0 | ||||
| 24. Ronde | 06.03.2022 | Mérida AD | - | Don Benito | 3:0 | |
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| 29. Ronde | 10.04.2022 | Don Benito | - | Xerez DFC | 1:2 | |
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| 30. Ronde | 17.04.2022 | Cádiz CF B | - | Don Benito | 2:1 | |
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| 33. Ronde | 08.05.2022 | UD Tamaraceite | - | Don Benito | 0:0 | ||||
| 34. Ronde | 15.05.2022 | Don Benito | - | UD San Fernando | 2:2 |
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