| 6. Ronde | 09.07.2021 | Defensor Sporting | - | Racing | 1:4 | ||||
| 7. Ronde | 15.07.2021 | Villa Teresa | - | Defensor Sporting | 0:2 | ||||
| 8. Ronde | 22.07.2021 | Defensor Sporting | - | Juventud de Las Piedras | 1:2 | ||||
| 9. Ronde | 28.07.2021 | Uruguay Montevideo | - | Defensor Sporting | 0:2 | ||||
| 10. Ronde | 05.08.2021 | Defensor Sporting | - | Rampla Juniors | 1:0 | ||||
| 11. Ronde | 14.08.2021 | Danubio | - | Defensor Sporting | 0:1 | ||||
| 17. Ronde | 20.10.2021 | Racing | - | Defensor Sporting | 0:1 | ||||
| 20. Ronde | 10.11.2021 | Defensor Sporting | - | Uruguay Montevideo | 2:0 |
Uruguay