| 1. Ronde | 12.09.2021 | Volos NFC | - | Lamia | 2:1 | ||||
| 2. Ronde | 19.09.2021 | Lamia | - | Olympiakos | 1:2 | ||||
| 3. Ronde | 22.09.2021 | AEK Athene | - | Lamia | 1:0 | ||||
| 4. Ronde | 26.09.2021 | Lamia | - | Panetolikos | 2:2 |  |
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| 5. Ronde | 03.10.2021 | Ionikos Nikea | - | Lamia | 1:2 |  |
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| 6. Ronde | 18.10.2021 | Lamia | - | Aris Saloniki | 0:1 | ||||
| 7. Ronde | 24.10.2021 | OFI Heraklion | - | Lamia | 0:0 | |
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| 8. Ronde | 31.10.2021 | Lamia | - | Atromitos | 2:2 | ||||
| 10. Ronde | 22.11.2021 | Lamia | - | Panathinaikos | 1:3 | |
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| 20. Ronde | 29.01.2022 | Lamia | - | OFI Heraklion | 2:1 | |
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| 23. Ronde | 13.02.2022 | Panathinaikos | - | Lamia | 2:0 | |
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| 17. Ronde | 16.02.2022 | Panetolikos | - | Lamia | 1:0 | ||||
| 24. Ronde | 20.02.2022 | Lamia | - | Apollon Smyrnis | 1:2 | |
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| 22. Ronde | 23.02.2022 | Lamia | - | Asteras Tripolis | 0:2 | ||||
| 26. Ronde | 06.03.2022 | Lamia | - | PAOK Saloniki | 0:2 |
Griekenland