| 1. Ronde | 21.08.2021 | Paphos FC | - | APOEL Nicosia | 4:0 | ||||
| 5. Ronde | 03.10.2021 | Anorthosis Famagusta | - | APOEL Nicosia | 2:1 | ||||
| 6. Ronde | 18.10.2021 | APOEL Nicosia | - | Ethnikos Achna | 2:1 | ||||
| 8. Ronde | 30.10.2021 | Doxa Katokopias | - | APOEL Nicosia | 2:2 | ||||
| 9. Ronde | 06.11.2021 | APOEL Nicosia | - | AEL Limassol | 3:0 | ||||
| 10. Ronde | 22.11.2021 | AEK Larnaca | - | APOEL Nicosia | 0:0 | ||||
| 12. Ronde | 05.12.2021 | APOEL Nicosia | - | Paphos FC | 1:1 | ||||
| 17. Ronde | 15.01.2022 | Ethnikos Achna | - | APOEL Nicosia | 0:3 | ||||
| 18. Ronde | 23.01.2022 | APOEL Nicosia | - | Aris Limassol | 1:1 | ||||
| 19. Ronde | 30.01.2022 | APOEL Nicosia | - | Doxa Katokopias | 2:0 | ||||
| 20. Ronde | 06.02.2022 | AEL Limassol | - | APOEL Nicosia | 2:3 | ||||
| 15. Ronde | 09.02.2022 | PAEEK | - | APOEL Nicosia | 1:3 |
Cyprus