| 1. Ronde | 23.02.2025 | Houston Dynamo | - | FC Dallas | 1:2 | ||||
| 2. Ronde | 03.03.2025 | Houston Dynamo | - | Inter Miami CF | 1:4 | ||||
| 3. Ronde | 08.03.2025 | Columbus Crew | - | Houston Dynamo | 0:0 | ||||
| 4. Ronde | 16.03.2025 | Houston Dynamo | - | Real Salt Lake | 1:2 | ||||
| 5. Ronde | 23.03.2025 | Seattle Sounders | - | Houston Dynamo | 0:0 | ||||
| 6. Ronde | 31.03.2025 | Portland Timbers | - | Houston Dynamo | 3:1 |  |
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| 7. Ronde | 06.04.2025 | Houston Dynamo | - | Los Angeles FC | 1:0 | ||||
| 8. Ronde | 13.04.2025 | Los Angeles Galaxy | - | Houston Dynamo | 1:1 | |
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| 9. Ronde | 20.04.2025 | Houston Dynamo | - | Colorado Rapids | 2:2 | ||||
| 10. Ronde | 27.04.2025 | Houston Dynamo | - | Austin FC | 2:0 | |
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| 11. Ronde | 04.05.2025 | Los Angeles FC | - | Houston Dynamo | 2:0 | |
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| 12. Ronde | 11.05.2025 | Houston Dynamo | - | Seattle Sounders | 1:3 | ||||
| 13. Ronde | 15.05.2025 | Houston Dynamo | - | Minnesota United FC | 2:0 | ||||
| 14. Ronde | 18.05.2025 | FC Dallas | - | Houston Dynamo | 0:2 |  |
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| 15. Ronde | 25.05.2025 | San Jose Earthquakes | - | Houston Dynamo | 3:3 | |
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| 16. Ronde | 29.05.2025 | New York City FC | - | Houston Dynamo | 0:3 | ||||
| 17. Ronde | 01.06.2025 | Houston Dynamo | - | Sporting Kansas City | 1:3 | |
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