| 1. Ronde | 20.08.2021 | Mamelodi Sundowns | - | AmaZulu FC | 1:0 | ||||
| 2. Ronde | 24.08.2021 | Chippa United | - | Mamelodi Sundowns | 0:0 | ||||
| 3. Ronde | 12.09.2021 | Mamelodi Sundowns | - | Kaizer Chiefs | 2:0 | ||||
| 4. Ronde | 19.09.2021 | Mamelodi Sundowns | - | TS Galaxy | 3:0 | ||||
| 5. Ronde | 25.09.2021 | Orlando Pirates | - | Mamelodi Sundowns | 0:2 | ||||
| 6. Ronde | 03.10.2021 | Mamelodi Sundowns | - | Moroka Swallows | 3:0 | ||||
| 7. Ronde | 20.10.2021 | Golden Arrows | - | Mamelodi Sundowns | 0:1 | ||||
| 9. Ronde | 03.11.2021 | Mamelodi Sundowns | - | Maritzburg United | 1:0 | ||||
| 11. Ronde | 20.11.2021 | Cape Town City FC | - | Mamelodi Sundowns | 0:0 | ||||
| 19. Ronde | 24.11.2021 | Mamelodi Sundowns | - | SuperSport United | 2:2 | ||||
| 12. Ronde | 27.11.2021 | Mamelodi Sundowns | - | Sekhukhune United | 2:0 | ||||
| 13. Ronde | 04.12.2021 | Stellenbosch FC | - | Mamelodi Sundowns | 1:1 |  |
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| 20. Ronde | 02.03.2022 | TS Galaxy | - | Mamelodi Sundowns | 0:3 |  |
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| 21. Ronde | 05.03.2022 | Maritzburg United | - | Mamelodi Sundowns | 2:1 | ||||
| 24. Ronde | 06.04.2022 | Moroka Swallows | - | Mamelodi Sundowns | 2:4 | ||||
| 29. Ronde | 14.05.2022 | Mamelodi Sundowns | - | Stellenbosch FC | 0:3 |
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